Christopherson W M, Connelly P J, Alberhasky R C
Cancer. 1983 May 1;51(9):1705-9. doi: 10.1002/1097-0142(19830501)51:9<1705::aid-cncr2820510924>3.0.co;2-c.
A review of the pathologic material from patients in our population based uterine cancer registry in Louisville, Kentucky identified three subtypes of endometrial carcinoma with a favorable prognosis: adenoacanthoma, adenocarcinoma with no specific features, and secretory carcinoma. Three subtypes with a much less favorable prognosis were papillary carcinoma, mixed adenosquamous carcinoma, and clear cell carcinoma. The other important determinants of treatment results were: stage of disease, age, race, nuclear grade, and depth of myometrial invasion. This study evaluated these prognostic determinants for the favorable subtypes with Stage 1 disease that were fully treated. There were 595 patient eligible for five-year and 380 for ten-year vital status evaluation. Only three patients were lost to follow-up at five years and four at ten years. The five-year survival was 88.1% and the ten-year 74.5%. At five years 4.4% were dead of disease and at ten years 6.3%. There were 115 women younger than age 50. Their five-year survival was 98.3% and at ten years 94.6%. None was dead of disease at five years and only one at ten years. Black women had a significantly lower survival than did white women, but no black woman younger than age 50 died of disease. Nuclear grade was the most important histologic determinant of survival, followed by depth of myometrial invasion. Recommendations for treatment planning were formulated based on these prognosticators.
对肯塔基州路易斯维尔市基于人群的子宫癌登记处患者的病理材料进行回顾，确定了三种预后良好的子宫内膜癌亚型：腺棘皮癌、无特定特征的腺癌和分泌性癌。三种预后差得多的亚型是乳头状癌、腺鳞混合癌和透明细胞癌。治疗结果的其他重要决定因素包括：疾病分期、年龄、种族、核分级和肌层浸润深度。本研究评估了这些预后决定因素对接受了充分治疗的Ⅰ期疾病的预后良好亚型的影响。有595名患者符合进行五年生命状态评估的条件，380名符合十年评估条件。五年时仅3名患者失访，十年时4名失访。五年生存率为88.1%，十年生存率为74.5%。五年时4.4%死于疾病，十年时6.3%。有115名年龄小于50岁的女性。她们的五年生存率为98.3%，十年生存率为94.6%。五年时无人死于疾病，十年时仅1人。黑人女性的生存率显著低于白人女性，但年龄小于50岁的黑人女性无一人死于疾病。核分级是生存的最重要组织学决定因素，其次是肌层浸润深度。基于这些预后因素制定了治疗计划建议。
