Minton J P, Walaszek Z, Schooley W, Hanausek-Walaszek M, Webb T E
Breast Cancer Res Treat. 1986;8(3):217-22. doi: 10.1007/BF01807334.
Certain enzymes in tissues and body fluids may, through reversal of the detoxification process, influence the composition and availability of steroid hormones, toxins, and carcinogens. The ubiquitous enzyme beta-glucuronidase, which hydrolyzes glucuronide conjugates, thereby reversing one of the main detoxification and excretion pathways, was found to vary in concentration in different cysts over a 300-fold range. The distribution was a continuum, devoid of discrete sub-populations. Evidence obtained on selected cyst fluids of high and low beta-glucuronidase activities indicated that the level of the enzyme significantly influenced the ratio of unconjugated: glucuronidated estradiol. The patients with fibrocystic breast disease fell into 2 distinct subpopulations on the basis of their serum beta-glucuronidase activity. In one group the activity was near normal, while in the second group the average serum beta-glucuronidase activity was 3-fold higher than in the women who did not have benign breast disease.
组织和体液中的某些酶可能通过解毒过程的逆转，影响类固醇激素、毒素和致癌物的组成及可用性。普遍存在的β-葡萄糖醛酸酶可水解葡萄糖醛酸共轭物，从而逆转主要的解毒和排泄途径之一，研究发现该酶在不同囊肿中的浓度变化范围达300倍。其分布是连续的，不存在离散的亚群。对选定的高β-葡萄糖醛酸酶活性和低β-葡萄糖醛酸酶活性的囊肿液的研究证据表明，该酶的水平显著影响未结合雌二醇与葡萄糖醛酸化雌二醇的比例。根据血清β-葡萄糖醛酸酶活性，患有纤维囊性乳腺病的患者可分为两个不同的亚群。一组的活性接近正常，而另一组的平均血清β-葡萄糖醛酸酶活性比未患良性乳腺病的女性高3倍。
