Fishman J, Fukushima D, O'Connor J, Rosenfeld R S, Lynch H T, Lynch J F, Guirgis H, Maloney K
Cancer Res. 1978 Nov;38(11 Pt 2):4006-11.
The plasma hormone concentrations of 30 young women, who were judged by genetic analysis to be at high risk for familial breast cancer, were compared with those of 30 matched controls identified as at low risk for the disease. The hormone measurements were obtained every second day throughout the menstrual cycle, and the results were analyzed in terms of follicular, luteal, and full-cycle mean concentrations. Comparison was carried out in a paired fashion with each high-risk and low-risk pair matched closely for height, weight, age, and reproductive history. No statistically significant differences were found in prolactin, gonadotropin, estrone, estradiol, or estriol plasma concentrations although the high-risk group displayed consistently lower values in all of the above except estriol.
通过基因分析判定为患家族性乳腺癌高风险的30名年轻女性的血浆激素浓度，与被确定为该病低风险的30名匹配对照者的血浆激素浓度进行了比较。在整个月经周期中每隔一天进行一次激素测量，并根据卵泡期、黄体期和全周期平均浓度对结果进行分析。以配对方式进行比较，每对高风险和低风险个体在身高、体重、年龄和生殖史方面紧密匹配。尽管高风险组在除雌三醇外的所有上述激素中血浆浓度始终较低，但在催乳素、促性腺激素、雌酮、雌二醇或雌三醇血浆浓度方面未发现统计学上的显著差异。
