Cavanagh A C, Morton H, Rolfe B E, Gidley-Baird A A
Am J Reprod Immunol (1980). 1982 Apr;2(2):97-101. doi: 10.1111/j.1600-0897.1982.tb00093.x.
Previous studies have shown that, in the mouse, a factor is produced by the fertilized ovum within 24 h of mating. It cooperates with prolactin to stimulate ovarian production of component B or early pregnancy factor (EPF). This paper presents an initial characterization of the substance, termed ovum factor (OF). An indirect assay based on the rosette inhibition test for EPF has shown that OF is first released upon penetration of the ovum by the fertilizing spermatozoon. OF continues to be produced at least until blastulation. Processes which parthenogenetically activate the ovum are also capable of stimulating OF release from unfertilized ova. Gel filtration studies reveal that OF exists in multiple MW forms of approximately 160,000; 2,800; and 1,500. A substance with these characteristics has not been described previously; it may represent the first embryonic signal to the mother.
先前的研究表明，在小鼠中，受精卵子在交配后24小时内会产生一种因子。它与催乳素协同作用，刺激卵巢产生成分B或早期妊娠因子（EPF）。本文对这种被称为卵子因子（OF）的物质进行了初步表征。基于EPF的玫瑰花结抑制试验的间接测定表明，OF在受精精子穿透卵子时首次释放。OF至少持续产生到囊胚形成。孤雌激活卵子的过程也能够刺激未受精卵释放OF。凝胶过滤研究表明，OF以多种分子量形式存在，约为160,000；2,800；和1,500。以前尚未描述过具有这些特征的物质；它可能代表了向母体发出的第一个胚胎信号。
