Fruchtman S M, Gombert M E, Lyons H A
Chest. 1983 Apr;83(4):598-601. doi: 10.1378/chest.83.4.598.
The Pneumococcus continues to be a common cause of infectious pneumonia; however, the cause of death in pneumococcal disease remains obscure. Ten patients are described who developed the adult respiratory distress syndrome (ARDS) secondary to pneumococcal pneumonia. The patients are young (median age, 33 years) and leukopenic (median white blood cell count, 2.1 cells/cu mm) and have a mortality of 50 percent (five patients). It is postulated that pulmonary sequestration of leukocytes may play a role in the pathogenesis of ARDS secondary to pneumococcal disease. Four different pneumococcal capsular subtypes (9V [68]; 9A [33]; 4; 3) were found capable of causing ARDS. The currently available pneumococcal vaccine does not contain two of the capsular subtypes associated with ARDS.
肺炎球菌仍然是感染性肺炎的常见病因；然而，肺炎球菌疾病的死因仍不明确。本文描述了10例继发于肺炎球菌肺炎的成人呼吸窘迫综合征（ARDS）患者。这些患者较为年轻（中位年龄33岁）且白细胞减少（中位白细胞计数为2.1个/立方毫米），死亡率为50%（5例患者）。据推测，白细胞在肺部的滞留可能在肺炎球菌疾病继发ARDS的发病机制中起作用。发现四种不同的肺炎球菌荚膜亚型（9V [68]；9A [33]；4；3）能够引起ARDS。目前可用的肺炎球菌疫苗并不包含与ARDS相关的两种荚膜亚型。
