Pei Y Q
Epilepsia. 1983 Apr;24(2):177-82. doi: 10.1111/j.1528-1157.1983.tb04877.x.
Piperine and its derivatives are effective anticonvulsant drugs that antagonize convulsions induced by physical and chemical methods. Their major anticonvulsant activity as shown in animal tests lies in modification of the maximal electroshock seizure pattern. They also have sedative-hypnotic, tranquilizing, and muscle-relaxing actions and can intensify the depressive action of other depressants, when used in combination. Antiepilepsirine, one of the derivatives of piperine, is used as an antiepileptic drug in treating different types of epilepsy. It has been proved effective and is being widely used in China. The anticonvulsant action of 7446, 7448, and 7903 is more potent than that of antiepilepsirine. The chemical structure of piperine and its derivatives is different from that of prototype antiepileptic drugs, and, therefore, these may become a new group of antiepileptic drugs.
胡椒碱及其衍生物是有效的抗惊厥药物，可拮抗物理和化学方法诱导的惊厥。动物试验显示，它们的主要抗惊厥活性在于改变最大电休克惊厥模式。它们还具有镇静催眠、安神和肌肉松弛作用，联合使用时可增强其他抑制剂的抑制作用。胡椒碱的衍生物之一抗痫灵用作治疗不同类型癫痫的抗癫痫药物。它已被证明有效，并在中国广泛使用。7446、7448和7903的抗惊厥作用比抗痫灵更强。胡椒碱及其衍生物的化学结构与原型抗癫痫药物不同，因此，它们可能成为一类新的抗癫痫药物。
