Viña J, Romero F J, Saez G T, Pallardó F V
Experientia. 1983 Feb 15;39(2):164-5. doi: 10.1007/BF01958877.
Intraperitoneal injections of cysteine or N-acetyl cysteine induce a depletion of reduced glutathione (GSH) in rat brain. The doses required to promote GSH depletion are lower than those reported to cause a disseminate neurodegenerative syndrome. Since physiological GSH concentrations are required to maintain cell membranes, we suggest that consideration of the cysteine-induced GSH depletion is important in attempts to understand the mechanism of cysteine-induced cytotoxicity in brain.
腹腔注射半胱氨酸或N-乙酰半胱氨酸会导致大鼠脑内还原型谷胱甘肽（GSH）耗竭。促进GSH耗竭所需的剂量低于据报道会引发弥漫性神经退行性综合征的剂量。由于维持细胞膜需要生理浓度的GSH，我们认为在试图理解半胱氨酸诱导脑内细胞毒性机制的过程中，考虑半胱氨酸诱导的GSH耗竭很重要。
