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放射性同位素法测定神经系统疾病患者脑脊液中的叶酸和维生素B12

Radioisotopic determination of cerebrospinal fluid (CSF) folic acid and vitamin B12 in neurological disorders.

作者信息

Papageorgiou C, Mavrikakis M, Kesse-Elias M, Anastasiou-Nana M, Germanides J

出版信息

Experientia. 1983 Apr 15;39(4):432-3. doi: 10.1007/BF01963167.

DOI:10.1007/BF01963167
PMID:6832334
Abstract

In a total of 55 samples of cerebrospinal fluid (CSF) and an equal number of serum samples obtained from 45 patients with neurological disorders and 10 controls, folic acid and vitamin B12 were measured. A radioisotopic assay method was used. A significant decrease of CSF folic acid was noted in the group with cerebral tumors.

摘要

在从45例神经系统疾病患者和10名对照者获取的总共55份脑脊液(CSF)样本以及相同数量的血清样本中,检测了叶酸和维生素B12。采用放射性同位素测定法。在脑肿瘤组中,脑脊液叶酸显著降低。

相似文献

1
Radioisotopic determination of cerebrospinal fluid (CSF) folic acid and vitamin B12 in neurological disorders.放射性同位素法测定神经系统疾病患者脑脊液中的叶酸和维生素B12
Experientia. 1983 Apr 15;39(4):432-3. doi: 10.1007/BF01963167.
2
Vitamin B12 and folate concentrations in serum and cerebrospinal fluid of neurological patients with special reference to multiple sclerosis and dementia.神经系统疾病患者血清和脑脊液中的维生素B12及叶酸浓度,特别涉及多发性硬化症和痴呆症
J Neurol Neurosurg Psychiatry. 1990 Nov;53(11):951-4. doi: 10.1136/jnnp.53.11.951.
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[Vitamin B12 and folic acid concentrations in serum and cerebrospinal fluid in neurological disorders].[神经疾病患者血清和脑脊液中维生素B12及叶酸浓度]
Duodecim. 1969;85(1):49-59.
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Vitamin B12 levels of cerebrospinal fluid in patients with a variety of neurological disorders.各种神经系统疾病患者脑脊液中的维生素B12水平。
J Nutr Sci Vitaminol (Tokyo). 1977;23(4):299-304. doi: 10.3177/jnsv.23.299.
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Abnormalities of vitamin B12 and folic acid metabolism--their influence on the nervous system.维生素B12和叶酸代谢异常——它们对神经系统的影响。
Proc Nutr Soc. 1968 Mar;27(1):101-7. doi: 10.1079/pns19680021.
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[Determination of myelin basic protein in the cerebrospinal fluid in neurologic diseases].[神经系统疾病患者脑脊液中髓鞘碱性蛋白的测定]
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Amnionless (AMN) mutations in Imerslund-Gräsbeck syndrome may be associated with disturbed vitamin B12 transport into the CNS.Imerslund-Gräsbeck综合征中的无羊膜蛋白(AMN)突变可能与维生素B12向中枢神经系统的转运障碍有关。
J Inherit Metab Dis. 2008 Dec;31 Suppl 3:493-6. doi: 10.1007/s10545-007-0760-2. Epub 2008 Jan 7.

本文引用的文献

1
Isotopic determination of serum vitamin B12 level using Sephadex G-25.
Nucl Med (Stuttg). 1967 Oct 15;6(3):311-20.
2
Lactobacillus casei C.S.F. folate activity.干酪乳杆菌C.S.F.的叶酸活性。
Br Med J. 1967 Sep 30;3(5569):834-6. doi: 10.1136/bmj.3.5569.834.
3
Cerebrospinal fluid folate, and vitamin B 12 in anticonvulsant-induced megaloblastosis.抗惊厥药所致巨幼细胞性贫血中的脑脊液叶酸和维生素B12
J Lab Clin Med. 1973 Jan;81(1):105-15.
4
Folate binding in animal plasma.
Acta Haematol. 1974;51(4):204-10. doi: 10.1159/000208295.
5
Folate transport in the central nervous system.中枢神经系统中的叶酸转运
Am J Physiol. 1975 Sep;229(3):777-82. doi: 10.1152/ajplegacy.1975.229.3.777.