Nijst T Q, Wevers R A, Schoonderwaldt H C, Hommes O R, de Haan A F
Institute of Neurology, University Hospital, Nijmegen, The Netherlands.
J Neurol Neurosurg Psychiatry. 1990 Nov;53(11):951-4. doi: 10.1136/jnnp.53.11.951.
Vitamin B12 and folate concentrations were measured in serum and cerebrospinal fluid (CSF) in 293 neurological patients. Serum and CSF vitamin B12 concentrations showed a positive correlation. In individual patients CSF B12 concentrations varied considerably for a given serum concentration. The median serum vitamin B12 concentration of the Alzheimer's type dementia group was significantly lower compared with that of a control group. Lower median CSF vitamin B12 concentrations were found in groups of patients with multiple sclerosis and Alzheimer's type dementia. Five patients with heterogeneous clinical pictures had unexplained low serum and CSF B12 concentrations without macrocytosis. Two patients had very high serum B12 and low-normal CSF concentrations which could be explained by a blood-brain barrier transport defect. Serum and CSF folate concentrations did not show significant differences between the various groups.
对293例神经系统疾病患者的血清和脑脊液（CSF）中的维生素B12和叶酸浓度进行了测定。血清和脑脊液维生素B12浓度呈正相关。对于个体患者，给定血清浓度下脑脊液B12浓度差异很大。阿尔茨海默型痴呆组的血清维生素B12浓度中位数显著低于对照组。多发性硬化症和阿尔茨海默型痴呆患者组的脑脊液维生素B12浓度中位数较低。5例临床表现各异的患者血清和脑脊液B12浓度 unexplained 偏低且无巨红细胞症。2例患者血清B12水平非常高，脑脊液浓度低至正常，这可能是由于血脑屏障转运缺陷所致。各亚组之间血清和脑脊液叶酸浓度无显著差异。 （注：原文中“unexplained”未翻译完整，可能是表述有误，正常应为“无法解释的”之类意思）
