Lewis J C, O'Flaherty J T, McCall C E, Wykle R L, Bond M G
Exp Mol Pathol. 1983 Feb;38(1):100-8. doi: 10.1016/0014-4800(83)90102-8.
Morphometric analysis of endothelium in rabbit lungs demonstrated a dramatic effect of platelet-activating factor (PAF) on the ultrastructure of pulmonary vasculature. Plasmalemmal vesicles in capillaries were increased both in size (638 A PAF vs 538 A control) and in number (386/micrograms 3 cytoplasm PAF vs 125/micrograms 3 cytoplasm control) when PAF was administered as a single acute low dose (chi less than 3 micrograms/kg). High concentrations of PAF (chi greater than 3 micrograms/kg) as a single acute dose also increased vesicle number (203/micrograms 3 cytoplasm), but frequently precipitated the respiratory distress syndrome. Chronic administration of PAF with daily doses over periods of either 3.5 or 7 weeks resulted in changes paralleling the acute observations, but did not lead to more extensive lung disease.
对兔肺内皮进行形态计量学分析显示，血小板活化因子（PAF）对肺血管超微结构有显著影响。当以单次急性低剂量（小于3微克/千克）给予PAF时，毛细血管中的质膜小泡大小（PAF组为638埃，对照组为538埃）和数量（PAF组每微克3细胞质中有386个，对照组每微克3细胞质中有125个）均增加。高浓度的PAF（大于3微克/千克）作为单次急性剂量也增加了小泡数量（每微克3细胞质中有203个），但常引发呼吸窘迫综合征。以每日剂量连续3.5周或7周慢性给予PAF，导致的变化与急性观察结果相似，但未导致更广泛的肺部疾病。
