McManus L M, Pinckard R N
Am J Pathol. 1985 Oct;121(1):55-68.
Acetyl glyceryl ether phosphorylcholine (AGEPC; 1-O-hexadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) was infused intravenously into rabbits (0.5 micrograms/kg); subsequently, temporal pulmonary alterations were assessed histologically. Within 30 seconds after AGEPC infusion, widespread platelet and neutrophil aggregates were distributed throughout the pulmonary microvasculature. Concomitantly, small muscular arteries and bronchioles throughout the lungs were contracted. Five minutes after AGEPC infusion, intravascular pulmonary platelet aggregates were less frequent and smaller than those observed at 30 seconds after infusion; however, AGEPC-induced pulmonary neutrophil sequestration persisted. Moreover, at this time, large mononucleated cells and damaged endothelial cells were prevalent throughout the pulmonary microvasculature. Sixty minutes after infusion, neither platelet aggregates nor arterial or bronchiolar constriction was observed. However, in most animals, neutrophils and large mononucleated cells were still abundant, and focal endothelial cell alterations persisted. In addition, discrete areas of interstitial hemorrhage around small and medium-sized arteries were present. These studies suggest that the intravascular release of AGEPC could initiate significant pulmonary injury and therefore could be an important etiologic factor in the development of inflammatory lung diseases.
将乙酰甘油醚磷酸胆碱（AGEPC；1-O-十六烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）以0.5微克/千克的剂量静脉注射到兔子体内；随后，通过组织学评估肺部随时间的变化。在注入AGEPC后30秒内，广泛的血小板和中性粒细胞聚集体分布在整个肺微血管系统中。与此同时，肺部各处的小肌性动脉和细支气管收缩。注入AGEPC后5分钟，血管内肺血小板聚集体比注入后30秒时更不频繁且更小；然而，AGEPC诱导的肺中性粒细胞滞留持续存在。此外，此时，大单核细胞和受损内皮细胞在整个肺微血管系统中普遍存在。注入后60分钟，未观察到血小板聚集体或动脉或细支气管收缩。然而，在大多数动物中，中性粒细胞和大单核细胞仍然大量存在，局部内皮细胞改变持续存在。此外，在中小动脉周围存在离散的间质出血区域。这些研究表明，AGEPC的血管内释放可引发严重的肺损伤，因此可能是炎症性肺病发展的重要病因。
