Punnonen R, Söderström K O
Eur J Obstet Gynecol Reprod Biol. 1983 Jan;14(4):217-24. doi: 10.1016/0028-2243(83)90263-0.
Postmenopausal women were given estriol succinate orally in a daily dose of 4 mg X 2 for 14 days or 4 mg X 2, 8 mg X 1 and 2 mg in the morning + 2 mg at noon + 4 mg in the evening for 4 wk. Each group consisted of 4 women. The effect of the estrogen treatment was estimated by the endometrial curettage samples taken both before and after the hormone treatment. The curettage samples were studied by both light and electron microscopy. The results showed that a treatment period of 4 wk was necessary to obtain any effect. When 8 mg of estriol succinate was given in a single dose only a slight effect was obtained on the endometrium but when the same dose was divided in 2 daily 4 mg parts, the endometrium showed clearly proliferative changes. Thus estriol is able to produce the same endometrial effect as estradiol. Ultrastructurally the hormone treatment caused an increase in the cytoplasm of the endometrial epithelial cells. Also, whorls of cytoplasmic microfilaments often appeared near the nucleus of the cells.
绝经后女性口服琥珀酸雌三醇，每日剂量为4毫克×2次，共14天；或4毫克×2次、8毫克×1次，且早上2毫克+中午2毫克+晚上4毫克，共4周。每组有4名女性。通过激素治疗前后采集的子宫内膜刮宫样本评估雌激素治疗的效果。刮宫样本通过光学显微镜和电子显微镜进行研究。结果表明，需要4周的治疗期才能产生任何效果。当仅单次给予8毫克琥珀酸雌三醇时，对子宫内膜只有轻微影响，但当相同剂量分为每日2个4毫克部分时，子宫内膜显示出明显的增殖变化。因此，雌三醇能够产生与雌二醇相同的子宫内膜效应。在超微结构上，激素治疗导致子宫内膜上皮细胞的细胞质增加。此外，细胞质微丝的螺旋通常出现在细胞核附近的细胞中。
