Englund D E, Johansson E D
Acta Obstet Gynecol Scand. 1980;59(5):449-51. doi: 10.3109/00016348009155427.
Estriol is a weak estrogen with a claimed specific action on the epithelium in cervix uteri and vagina and with no or limited ability to induce endometrial proliferation. In a previous pharmacokinetic study we have shown elevated estriol levels for only 2-3 hours after oral administration of the drug. The present study was performed to test if estriol, when given orally in daily divided doses to postmenopausal women, has any effect on the endometrium. Twenty postmenopausal women who had no vaginal bleeding in response to lynestrenol (Orgametil 5 mgX2XV) were treated with 6 mg estriol a day (Ovesterin 2 mgX3), divided into three doses, for 2 up to 3.5 months. When lynestrenol (5 mgX2XV) was given following the estriol treatment periods, 12 women out of 20 experienced a vaginal bleeding and one reported spotting. Endometrial biopsies in ten of these women who had a bleeding were examined histologically. The endometrium was atrophic in four women, proliferative in two, slightly hyperplastic in one and showed signs of weak hormonal activity in one. Two women had secretory endometrium. It is concluded that estriol, administered in a way that gives prolonged elevation of the blood levels, is able to produce the same effect on the endometrium as other estrogens.
雌三醇是一种弱雌激素，据称对子宫颈和阴道上皮有特定作用，诱导子宫内膜增殖的能力无或有限。在之前的一项药代动力学研究中，我们发现口服该药物后雌三醇水平仅在2 - 3小时内升高。本研究旨在测试绝经后妇女每日分剂量口服雌三醇时，对子宫内膜是否有任何影响。20名对炔雌醇（炔雌醇5mg×2×V）无阴道出血反应的绝经后妇女，每天服用6mg雌三醇（雌三醇2mg×3），分三次给药，持续2至3.5个月。在雌三醇治疗期后给予炔雌醇（5mg×2×V）时，20名妇女中有12名出现阴道出血，1名报告有点滴出血。对其中10名有出血的妇女进行了子宫内膜活检并进行组织学检查。4名妇女的子宫内膜萎缩，2名增殖，1名轻度增生，1名显示出弱激素活性迹象。2名妇女的子宫内膜呈分泌期。结论是，以能使血药浓度长时间升高的方式给药的雌三醇，对子宫内膜能产生与其他雌激素相同的作用。
