Tsukuma H, Mishima T, Oshima A
Int J Cancer. 1983 Apr 15;31(4):421-6. doi: 10.1002/ijc.2910310405.
In order to elucidate the natural history of early gastric cancer, we followed up non-concurrently certain patients who had been diagnosed endoscopically as having "early' gastric cancer and who had histological evidence of cancer by biopsy, but on whom surgical resection had been delayed or had not been conducted. At the Center for Adult Diseases, Osaka, 56 cases were eligible for this study. Out of these, 27 cases progressed to advanced cancer and 16 remained at the early stage during the follow-up period (6-88 months, mean: 29 months). The remaining 13 cases had had neither surgical resection nor examinations. The survivorship function for the duration of "early" gastric cancer was estimated by the life-table method of Kaplan and Meier. The median of the duration was estimated as 37 months. The 5-year survival rate of the 34 cases on whom surgical resection had not been conducted was estimated as 64.5%. These results suggest that early diagnosis and early treatment may lead to a reduction of mortality from stomach cancer.
为了阐明早期胃癌的自然病程，我们对部分经内镜诊断为“早期”胃癌且活检有癌症组织学证据，但手术切除延迟或未进行手术的患者进行了非同期随访。在大阪成人病中心，56例患者符合本研究条件。其中，27例进展为进展期癌，16例在随访期间（6 - 88个月，平均29个月）仍处于早期。其余13例既未接受手术切除也未接受检查。采用Kaplan - Meier寿命表法估计“早期”胃癌病程的生存函数。病程中位数估计为37个月。34例未进行手术切除患者的5年生存率估计为64.5%。这些结果表明，早期诊断和早期治疗可能会降低胃癌死亡率。
