Heigenhauser G J, Sutton J R, Jones N L
J Appl Physiol Respir Environ Exerc Physiol. 1983 Feb;54(2):470-4. doi: 10.1152/jappl.1983.54.2.470.
Five male subjects performed two graded exercise studies, one during control conditions and the other after reduction of muscle glycogen content by repeated maximum exercise and a high fat-protein diet. Reduction in preexercise muscle glycogen from 59.1 to 17.1 mumol X g-1 (n = 3) was associated with a 14% reduction in maximum power output but no change in maximum O2 intake; at any given power output O2 intake, heart rate, and ventilation (VE) were significantly higher, CO2 output (VCO2) was similar, and the respiratory exchange ratio was lower during glycogen depletion compared with control. The higher VE during glycogen depletion was associated with a higher VE/VCO2 ratio, lower end-tidal and mixed venous CO2 partial pressures, and higher blood pH than in the control studies. Changes in exercise VE accompanying glycogen depletion were not explained by changes in CO2 flux to the lungs suggesting that other factors served to modulate VE in these experimental conditions.
五名男性受试者进行了两项分级运动研究，一项在对照条件下进行，另一项在通过重复最大运动和高脂高蛋白饮食降低肌肉糖原含量后进行。运动前肌肉糖原从59.1微摩尔×克-1降至17.1微摩尔×克-1（n = 3）与最大功率输出降低14%相关，但最大摄氧量无变化；在任何给定的功率输出下，糖原耗竭期间的摄氧量、心率和通气量（VE）显著更高，二氧化碳输出量（VCO2）相似，呼吸交换率更低。与对照研究相比，糖原耗竭期间较高的VE与较高的VE/VCO2比值、较低的呼气末和混合静脉二氧化碳分压以及较高的血液pH值相关。糖原耗竭伴随的运动VE变化不能用肺二氧化碳通量的变化来解释，这表明在这些实验条件下，其他因素起到了调节VE的作用。
