Kowalchuk J M, Heigenhauser G J, Jones N L
J Appl Physiol Respir Environ Exerc Physiol. 1984 Nov;57(5):1558-63. doi: 10.1152/jappl.1984.57.5.1558.
Six healthy male subjects performed three exercise tests in which the power output was increased by 100 kpm/min each minute until exhaustion. The studies were carried out after oral administration of CaCO3 (control), NH4Cl (metabolic acidosis), and NaHCO3 (metabolic alkalosis). Ventilation (VE), O2 intake (VO2), and CO2 output (VCO2) were monitored continuously. Arterialized-venous blood samples were drawn at specific times and analyzed for pH, PCO2, and lactate concentration. Resting pH (mean +/- SE) was lowest in acidosis (7.29 +/- 0.01) and highest in alkalosis (7.46 +/- 0.02). A lower peak power output (kpm/min) was achieved in acidosis (1,717 +/- 95) compared with control (1,867 +/- 120) alkalosis (1,867 +/- 125). Submaximal VO2 and VCO2 were similar, but peak VO2 and VCO2 were lower in acidosis. Plasma lactate concentration was lower at rest and during exercise in acidosis. Although lactate accumulation was reduced in acidosis, increases in hydrogen ion concentration were similar in the three conditions. We conclude that acid-base changes influence the maximum power output that may be sustained in incremental dynamic exercise and modify plasma lactate appearance, but have little effect on hydrogen ion appearance in plasma.
六名健康男性受试者进行了三项运动测试，运动过程中功率输出以每分钟100千帕米的速度递增，直至力竭。这些研究在口服碳酸钙（对照组）、氯化铵（代谢性酸中毒）和碳酸氢钠（代谢性碱中毒）后进行。持续监测通气量（VE）、氧气摄入量（VO2）和二氧化碳排出量（VCO2）。在特定时间采集动脉化静脉血样本，分析其pH值、PCO2和乳酸浓度。静息pH值（平均值±标准误）在酸中毒时最低（7.29±0.01），在碱中毒时最高（7.46±0.02）。与对照组（1867±120）和碱中毒组（1867±125）相比，酸中毒组达到的峰值功率输出（千帕米/分钟）更低（1717±95）。次最大摄氧量和二氧化碳排出量相似，但酸中毒时的峰值摄氧量和二氧化碳排出量更低。酸中毒时静息和运动期间血浆乳酸浓度更低。尽管酸中毒时乳酸积累减少，但三种情况下氢离子浓度的增加相似。我们得出结论，酸碱变化会影响递增动态运动中可维持的最大功率输出，并改变血浆乳酸的出现，但对血浆中氢离子的出现影响不大。
