Glowa J R, Barrett J E
J Exp Anal Behav. 1983 Jan;39(1):165-73. doi: 10.1901/jeab.1983.39-165.
Responding of pigeons, maintained under a fixed-interval 3-minute schedule of food presentation, was decreased on days that the color of the lights illuminating the food magazine was changed and d-amphetamine (1.0 mg/kg, i.m.) was injected after the session. Responding was not decreased by keylight color changes paired with postsession d-amphetamine or by postsession injections of saline. Administration of pentobarbital (3.0 to 5.6 mg/kg), but not d-amphetamine (.3 to 3.0 mg/kg), before the session increased rates of responding suppressed by drug-paired magazine lights. Responding maintained under a fixed-ratio 30-response schedule was not decreased when differently colored magazine lights were paired with a low (.3 mg/kg) postsession dose of d-amphetamine; with high (3.0 mg/kg) postsession doses, however, responding was completely suppressed after two pairings. The effects of pairing magazine stimuli with an intermediate (1.0 mg/kg) postsession dose of d-amphetamine depended upon the magnitude of prior postsession doses. After being paired with a low dose, stimuli paired with 1.0 mg/kg did not suppress responding. After being paired with a high dose, stimuli paired with 1.0 mg/kg completely suppressed responding. The suppression of food-maintained responding by stimuli paired with postsession drug administration depends upon both behavioral and pharmacological variables.
在按固定间隔3分钟呈现食物的时间表下饲养的鸽子，在照亮食物盒的灯光颜色改变且在实验结束后注射d-苯丙胺（1.0毫克/千克，肌肉注射）的日子里，反应减少。与实验后注射d-苯丙胺配对的按键灯光颜色变化或实验后注射生理盐水并不会使反应减少。在实验前给予戊巴比妥（3.0至5.6毫克/千克）而非d-苯丙胺（0.3至3.0毫克/千克），会增加被药物配对的食物盒灯光抑制的反应速率。当不同颜色的食物盒灯光与低剂量（0.3毫克/千克）的实验后d-苯丙胺配对时，按固定比率30次反应时间表维持的反应不会减少；然而，在高剂量（3.0毫克/千克）的实验后给药情况下，两次配对后反应被完全抑制。将食物盒刺激与中等剂量（1.0毫克/千克）的实验后d-苯丙胺配对的效果取决于先前实验后剂量的大小。在与低剂量配对后，与1.0毫克/千克配对的刺激不会抑制反应。在与高剂量配对后，与1.0毫克/千克配对的刺激会完全抑制反应。与实验后药物给药配对的刺激对食物维持反应的抑制取决于行为和药理学变量。
