Hommes O R, Aerts F, Bahr U, Schulten H R
J Neurol Sci. 1983 Feb;58(2):297-303. doi: 10.1016/0022-510x(83)90224-1.
The cyclophosphamide content of urine, serum and spinal fluid of immuno-suppressed multiple sclerosis patients was determined using a newly developed off-line combination of high pressure liquid chromatography and field desorption mass spectrometry. Although urinary excretion of the drug varied considerably between patients, the levels in serum and spinal fluid were in the same range, a relationship that may facilitate control of the dosage.
采用新开发的高压液相色谱与场解吸质谱联用离线分析法，测定了免疫抑制的多发性硬化症患者尿液、血清和脑脊液中的环磷酰胺含量。尽管患者之间药物的尿排泄量差异很大，但血清和脑脊液中的含量处于同一范围，这种关系可能有助于控制剂量。
