Gatti J E, LaRossa D, Silverman D G, Hartford C E
J Trauma. 1983 Mar;23(3):202-6. doi: 10.1097/00005373-198303000-00004.
Determination of depth of burn injury using vital dyes has been unsatisfactory. The present study evaluated the ability of the fiberoptic perfusion fluorometer to assess the depth of burn in the early postburn period. Sixty-three burns were examined with the fluorometer after intravenous administration of sodium fluorescein. The fluorescein kinetics were monitored for 1 hour within the first 48 hours and again between the third and sixth days postburn. The rate of fluorescein uptake and burn wound fluorescence was determined and compared to that of normal unburned skin. Depth of burn was confirmed by biopsy and healing characteristics. Fluorometric analysis during both study periods consistently distinguished between partial-thickness and full-thickness burns. Partial-thickness burns uniformly exhibited fluorescence within 10 minutes; full-thickness burns showed nil fluorescence. None of the patients experienced a change in skin color or complications from the small dose of fluorescein given.
使用活性染料确定烧伤深度并不理想。本研究评估了光纤灌注荧光计在烧伤后早期评估烧伤深度的能力。在静脉注射荧光素钠后，用荧光计检查了63处烧伤。在烧伤后的头48小时内监测荧光素动力学1小时，并在烧伤后第三天至第六天再次监测。测定荧光素摄取率和烧伤创面荧光，并与正常未烧伤皮肤进行比较。通过活检和愈合特征确定烧伤深度。在两个研究期间的荧光分析始终能够区分浅度烧伤和深度烧伤。浅度烧伤在10分钟内均呈现荧光；深度烧伤则无荧光显示。给予小剂量荧光素后，没有患者出现皮肤颜色变化或并发症。
