Burke J P, Jacobson J A, Garibaldi R A, Conti M T, Alling D W
J Urol. 1983 Feb;129(2):331-4. doi: 10.1016/s0022-5347(17)52083-2.
Meatal care with a poly-antibiotic ointment twice daily was evaluated in a prospective, randomized, controlled study of patients with temporary indwelling urethral catheters. Bacteriuria was acquired in 14 of 214 patients treated (6.5 per cent), compared to 16 of 214 patients not given treatment (7.5 per cent). The rate of bacteriuria was slightly lower in the treated than in the untreated group by each of 4 different statistical methods. In a subset of female patients at high risk a significant reduction in the rate of bacteriuria in treated patients was found by 1 method of analysis. These results contrast to previous studies in our hospital in which meatal care, using either nonantiseptic soap and water or an iodophor solution and ointment, was found to predispose to bacteriuria in high risk female patients. The benefit, if any, of meatal care with poly-antibiotic ointment appears to be small.
在一项针对留置临时尿道导管患者的前瞻性、随机、对照研究中，评估了每日两次使用多抗生素软膏进行尿道口护理的效果。接受治疗的214名患者中有14名发生菌尿（6.5%），未接受治疗的214名患者中有16名发生菌尿（7.5%）。通过4种不同的统计方法，治疗组的菌尿发生率均略低于未治疗组。在一部分高危女性患者中，通过一种分析方法发现治疗患者的菌尿发生率显著降低。这些结果与我院之前的研究形成对比，在之前的研究中，使用非抗菌肥皂和水或碘伏溶液及软膏进行尿道口护理，被发现会使高危女性患者易患菌尿。使用多抗生素软膏进行尿道口护理的益处（如果有的话）似乎很小。
