Burke J P, Garibaldi R A, Britt M R, Jacobson J A, Conti M, Alling D W
Am J Med. 1981 Mar;70(3):655-8. doi: 10.1016/0002-9343(81)90591-x.
To evaluate the efficacy of daily cleansing of the urethral meatus-catheter junction in preventing bacteriuria during closed urinary drainage, randomized, controlled trials of two widely recommended regimens for meatal care were completed. In 32 (16.0 percent) of 200 patients given twice daily applications of a povidone-iodine solution and ointment bacteriuria was acquired, as compared with 24 (12.4 percent) of 194 patients not given this treatment. In 28 (12.2 percent) of 229 patients given once daily meatal cleansing with a nonantiseptic solution of green soap and water bacteriuria was acquired, as compared with 18 (8.1 percent) of 23 patients not given special meatal care. There was no evidence in either trial of a beneficial effect of meatal care. Moreover, each of four different statistical methods indicated that the rates of bacteriuria were higher in the treated groups than in the untreated groups. In subsets of female patients at high risk in both studies significantly higher rates of bacteriuria were noted in the treated groups than in the untreated groups. Current methods of meatal care appear to be hazardous, as well as expensive, and cannot be recommended as measures to control infection.
为评估尿道口 - 导尿管连接处每日清洁在预防密闭式尿液引流期间菌尿症方面的疗效，针对两种广泛推荐的尿道口护理方案进行了随机对照试验。在200例每天两次应用聚维酮碘溶液和软膏的患者中，有32例（16.0%）发生了菌尿症，而194例未接受该治疗的患者中有24例（12.4%）发生菌尿症。在229例每天用绿色肥皂和水的非抗菌溶液进行尿道口清洁的患者中，有28例（12.2%）发生了菌尿症，而23例未接受特殊尿道口护理的患者中有18例（8.1%）发生菌尿症。两项试验均未发现尿道口护理有有益效果的证据。此外，四种不同的统计方法均表明，治疗组的菌尿症发生率高于未治疗组。在两项研究中女性高危亚组中，治疗组的菌尿症发生率显著高于未治疗组。目前的尿道口护理方法似乎既危险又昂贵，不能作为控制感染的措施推荐。
