Lindström S, Fall M, Carlsson C A, Erlandson B E
J Urol. 1983 Feb;129(2):405-10. doi: 10.1016/s0022-5347(17)52127-8.
Intravaginal electrical stimulation (IVS) induces a profound bladder inhibition and is successful in the treatment of incontinence due to detrusor instability. In this experimental study in cats, direct recordings of the efferent activity in thin hypogastric and pelvic nerve filaments to the bladder were used to analyze the neuronal mechanisms underlying this bladder inhibition. A longlasting reflex discharge, with a latency of 35 to 50 msec., was evoked in the hypogastric nerve by IVS. The reflex discharge was unaffected by imposed changes in intravesical pressure or by micturition contractions, but the response was very frequency-sensitive with an optimal transmission at about 5 Hz of stimulation. A "spontaneous" efferent activity could be recorded in the pelvic nerve filaments when the bladder pressure was elevated above 5 to 7 cm. H2O. The pelvic activity occurred in 10 to 20-second bursts, each followed by an abortive detrusor contraction. IVS of 5 to 10 Hz completely abolished this efferent pelvic activity by central inhibition. The findings are discussed in relation to the normal neuronal control of the bladder and to the clinical application of IVS.
阴道内电刺激（IVS）可引起膀胱深度抑制，成功用于治疗逼尿肌不稳定所致的尿失禁。在这项针对猫的实验研究中，通过直接记录膀胱下腹下神经和盆神经细纤维的传出活动，来分析这种膀胱抑制的神经机制。IVS可在腹下神经中诱发持续时间较长的反射性放电，潜伏期为35至50毫秒。反射性放电不受膀胱内压变化或排尿收缩的影响，但该反应对频率非常敏感，在约5赫兹的刺激频率下传输最佳。当膀胱压力升高至5至7厘米水柱以上时，可在盆神经细纤维中记录到“自发性”传出活动。盆神经活动以10至20秒的阵发形式出现，每次阵发后都伴有一次无效的逼尿肌收缩。5至10赫兹的IVS通过中枢抑制完全消除了这种盆神经传出活动。结合膀胱的正常神经控制以及IVS的临床应用对这些发现进行了讨论。
