Hui F W, Sun C J, Tocus E C, Hanig J P
Life Sci. 1983 Apr 4;32(14):1531-8. doi: 10.1016/0024-3205(83)90857-3.
Antinociception (ANTI) was assessed in male CD-1 mice by a modification of Haffner's tail clamp procedure. Studies revealed that tripelennamine (Tp) alone produced antinociception (ANTI) in mice and also caused potentiation when combined with morphine (M) or nalbuphene (NB). Naloxone (Nx) only partially blocked the effect of Tp, but fully blocked M. Although atropine (At) had no intrinsic ANTI activity, it enhanced that of Tp but not M. Histamine (Hm) had no intrinsic ANTI activity, nor did it interact with either Tp or M. The partial abolition of Tp ANTI, in contrast to complete blockade of M effects with Nx, appears to indicate that Tp can stimulate the opiate receptor as well as another receptor for ANTI at a different locus. The combination of Tp with various opiates may have considerable abuse potential.
通过对哈夫纳尾夹法进行改进，在雄性CD - 1小鼠中评估抗伤害感受（ANTI）。研究表明，单独使用曲吡那敏（Tp）可使小鼠产生抗伤害感受（ANTI），并且与吗啡（M）或纳布啡（NB）联合使用时会产生增效作用。纳洛酮（Nx）仅部分阻断Tp的作用，但能完全阻断M的作用。虽然阿托品（At）本身没有抗伤害感受活性，但它增强了Tp的抗伤害感受作用，而对M没有增强作用。组胺（Hm）本身没有抗伤害感受活性，也不与Tp或M相互作用。与Nx完全阻断M的作用相反，Tp的抗伤害感受作用只是部分被消除，这似乎表明Tp可以刺激阿片受体以及另一个位于不同位点的抗伤害感受受体。Tp与各种阿片类药物联合使用可能具有相当大的滥用潜力。
