Morris G, Seidler F J, Slotkin T A
Life Sci. 1983 Apr 4;32(14):1565-71. doi: 10.1016/0024-3205(83)90862-7.
Ornithine decarboxylase (ODC) initiates the synthesis of polyamines which play key roles in regulation of cellular development. Intracisternal administration of histamine or norepinephrine to developing rats produced age-dependent stimulation of ODC in brain. In cerebral cortex and ponsmedulla, stimulation by norepinephrine was demonstrable at postnatal day 7 and maximum stimulation occurred at about day 9. In contrast, cerebellum showed no initial reactivity to norepinephrine but still developed a large peak of response capability by day 9. In all 3 regions, the response declined rapidly thereafter during the period of major synaptogenesis of noradrenergic pathways. With histamine, none of the regions displayed ODC reactivity at 7 days postnatally; stimulation appeared by day 9, peaked at about day 11 and then declined rapidly. Thus, the trophic effect of histamine or norepinephrine toward ODC activity is present or develops postnatally and appears to terminate with synaptogenesis and onset of neurotransmitter properties of the amines.
鸟氨酸脱羧酶（ODC）启动多胺的合成，多胺在细胞发育调节中起关键作用。向发育中的大鼠脑池内注射组胺或去甲肾上腺素，会对脑内的ODC产生年龄依赖性刺激。在大脑皮层和脑桥延髓，去甲肾上腺素的刺激在出生后第7天即可显现，最大刺激出现在约第9天。相比之下，小脑对去甲肾上腺素最初没有反应，但到第9天仍会出现一个大的反应能力峰值。在所有这三个区域，此后在去甲肾上腺素能通路主要突触形成期间，反应迅速下降。对于组胺，在出生后7天，这些区域均未显示ODC反应性；刺激在第9天出现，在约第11天达到峰值，然后迅速下降。因此，组胺或去甲肾上腺素对ODC活性的营养作用在出生后存在或发展，并似乎随着突触形成和胺类神经递质特性的出现而终止。
