Vos P, Kaufmann D, Hand P J, Wolfe B B
School of Medicine, Department of Pharmacology, University of Pennsylvania, Philadelphia 19104.
Proc Natl Acad Sci U S A. 1990 Jul;87(13):5114-8. doi: 10.1073/pnas.87.13.5114.
Autoradiography has been used to visualize independently the subtypes of beta-adrenergic receptors in rat somatosensory cortex. Beta 2-Adrenergic receptors, but not beta 1-adrenergic receptors colocalize with "whisker barrels" in this tissue. Thus, each whisker sends a specific multisynaptic pathway to the somatosensory cortex that can be histochemically visualized and only one subtype of beta-adrenergic receptor is specifically associated with this cortical representation. Additionally, neonatal lesion of any or all of the whisker follicles results in loss of the corresponding barrel(s) as shown by histochemical markers. This loss is paralleled by a similar loss in the organization of beta 2-adrenergic receptors in the somatosensory cortex. Other results indicate that these beta 2-adrenergic receptors are not involved in moment-to-moment signal transmission in this pathway and, additionally, are not involved in a gross way in the development of whisker-barrel array.
放射自显影术已被用于独立观察大鼠体感皮层中β-肾上腺素能受体的亚型。在该组织中，β2-肾上腺素能受体而非β1-肾上腺素能受体与“触须桶”共定位。因此，每根触须向体感皮层发送一条特定的多突触通路，该通路可通过组织化学方法观察到，并且只有一种β-肾上腺素能受体亚型与这种皮层表征特异性相关。此外，如组织化学标记所示，任何一个或所有触须毛囊的新生期损伤都会导致相应“桶”的丧失。这种丧失与体感皮层中β2-肾上腺素能受体组织的类似丧失同时发生。其他结果表明，这些β2-肾上腺素能受体不参与该通路中即时的信号传递，此外，也未以显著方式参与触须-桶阵列的发育。
