流体静压对氟烷诱导的线粒体呼吸抑制的影响。

Effect of hydrostatic pressure on halothane-induced depression of mitochondrial respiration.

作者信息

Cohen P J

出版信息

Life Sci. 1983 Apr 4;32(14):1647-50. doi: 10.1016/0024-3205(83)90872-x.

Abstract

Anesthetized animals are awakened when subjected to increased atmospheric pressure. Whether all phenomena associated with the anesthetic state are similarly reversed is not known. Since the anesthetic halothane produces a dose-related reversible depression of rat liver mitochondrial respiration, the effect of 51 atmospheres of pressure on the drug's action was evaluated. It is concluded that application of pressure does not antagonize the inhibition produced by this anesthetic.

摘要

麻醉的动物在受到大气压升高作用时会苏醒。与麻醉状态相关的所有现象是否也会以类似方式逆转尚不清楚。由于麻醉药氟烷会产生与剂量相关的大鼠肝脏线粒体呼吸可逆性抑制，因此评估了51个大气压对该药物作用的影响。得出的结论是，施加压力不会拮抗这种麻醉药产生的抑制作用。