Cohen P J
Department of Anesthesia, University of Pennsylvania Medical School, Philadelphia 19104.
Can J Anaesth. 1989 Jan;36(1):40-3. doi: 10.1007/BF03010885.
Hydrostatic pressure antagonizes some, but not all, of the phenomena associated with general anaesthesia. For example, while unconsciousness produced by general anaesthesia in a wide variety of species is reversed by compression, anaesthetic-induced inhibition of synaptic transmission is potentiated by application of pressure. To date, the effect of pressure on analgesia has not been evaluated. In this study, hyperbaric pressure of 75 ata did not antagonize analgesia which had been produced by exposure of mice to 1.2 ata of nitrous oxide. However, the same hyperbaric pressure restored righting in animals which had been anesthetized with 1.5 ata of nitrous oxide. These data add to the suggestion that the multiple effects of general anaesthetics may be mediated at different loci.
流体静压能对抗一些但并非所有与全身麻醉相关的现象。例如，虽然在多种物种中由全身麻醉产生的意识丧失可通过加压逆转，但施加压力会增强麻醉诱导的突触传递抑制。迄今为止，尚未评估压力对镇痛的影响。在本研究中，75个绝对大气压的高压并未对抗小鼠暴露于1.2个绝对大气压氧化亚氮所产生的镇痛作用。然而，相同的高压使用1.5个绝对大气压氧化亚氮麻醉的动物恢复了翻正反射。这些数据进一步表明全身麻醉的多种效应可能在不同位点介导。
