Cohen P J, Bedows E, Brabec M J, Knight P R
Life Sci. 1985 Sep 30;37(13):1221-4. doi: 10.1016/0024-3205(85)90133-x.
Although anesthetized animals are awakened when subjected to increased pressure, compression does not result in antagonism of all phenomena associated with these drugs. It has recently been demonstrated that halothane's inhibition of respiration of isolated rat liver mitochondria is not reversed by hydraulic compression to 51 atmospheres. In order to determine whether this phenomenon can be extrapolated to the whole cell, we have investigated the effect of hydraulic compression of intact renal cells equilibrated with halothane, and conclude that pressure does not overcome the inhibitory effect of this anesthetic.
尽管麻醉动物在受到压力增加时会苏醒，但加压并不会消除与这些药物相关的所有现象。最近有研究表明，液压加压至51个大气压并不能逆转氟烷对离体大鼠肝线粒体呼吸的抑制作用。为了确定这种现象是否可以外推到整个细胞，我们研究了用氟烷平衡的完整肾细胞液压加压的效果，并得出结论：压力并不能克服这种麻醉剂的抑制作用。
