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使用小鼠精子形态学试验评估10种农药的潜在睾丸毒性。

An assessment of the potential testicular toxicity of 10 pesticides using the mouse-sperm morphology assay.

作者信息

Osterloh J, Letz G, Pond S, Becker C

出版信息

Mutat Res. 1983 Mar;116(3-4):407-15. doi: 10.1016/0165-1218(83)90079-4.

DOI:10.1016/0165-1218(83)90079-4
PMID:6835254
Abstract

Dinitrobutylphenol, chlorbenzilate, atrazine, Ordram, Telone (dichloropropene), pentachlorophenol (technical and reagent grades), Benomyl, DBCP (dibromochloropropane), and carbaryl were tested over a range of 7 doses in the mouse to assess their testicular toxicity. Measures of potential toxicity were sperm morphology, sperm counts and testicular weights. Each pesticide was injected intra-peritoneally in a single dose on each of 5 days. Testicular toxicity was assessed at 35 days. None of the pesticides tested, including the known human male testicular toxin, DBCP, produced statistically significant differences in the parameters from vehicle-injected controls.

摘要

对二硝基丁基苯酚、乙酯杀螨醇、莠去津、草乃敌、威百亩(二氯丙烯)、五氯苯酚(工业级和试剂级)、苯菌灵、二溴氯丙烷(DBCP)和西维因在小鼠体内进行了7种剂量范围的测试,以评估它们对睾丸的毒性。潜在毒性的衡量指标为精子形态、精子数量和睾丸重量。每种杀虫剂在5天中的每一天以单剂量腹腔注射。在35天时评估睾丸毒性。所测试的杀虫剂中,包括已知的人类男性睾丸毒素二溴氯丙烷(DBCP),与注射赋形剂的对照组相比,在各项参数上均未产生统计学上的显著差异。

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