Katzberg R W, Morris T W, Schulman G, Caldicott W J, Boylan L M, Foley M J, Spataro R F, Fischer H W
Radiology. 1983 May;147(2):331-4. doi: 10.1148/radiology.147.2.6836113.
Growing concern about acute renal failure as the result of contrast agents prompted an investigation into the renal effects of intravenous contrast materials in euvolemic and dehydrated dogs. Bolus injection of hypertonic agents induced marked reductions in filtration fraction and glomerular filtration rate in both groups of animals; however, these changes were transient, returning to near-base-line values within 30 minutes after injection. The most striking differences between euvolemic and dehydrated animals appeared to be related to prerenal factors such as hypovolemia and contrast-induced hypotension.
对造影剂导致急性肾衰竭的日益关注促使人们对静脉注射造影剂在血容量正常和脱水犬中的肾脏影响进行研究。在两组动物中，静脉推注高渗剂均导致滤过分数和肾小球滤过率显著降低；然而，这些变化是短暂的，注射后30分钟内恢复到接近基线值。血容量正常和脱水动物之间最显著的差异似乎与肾前因素有关，如血容量不足和造影剂引起的低血压。
