Whitehead C C, Siller W G
Res Vet Sci. 1983 Jan;34(1):73-6.
Turkeys were fed up to four weeks of age on diets of low biotin content and then fasted for 18 hours. Three birds developed clinical signs of fatty liver and kidney syndrome (FLKS) and on autopsy had pale and swollen livers and kidneys. Morphological studies showed fatty accumulations in liver, kidney, heart and proventriculus but no signs of inflammatory or degenerative changes. The infiltrated lipid had an abnormal fatty acid composition, with an increased proportion of monounsaturated fatty acids. Affected birds suffered from severe hypoglycaemia and hepatic glycogen was depleted. These findings demonstrate that FLKS can be induced experimentally in turkeys.
火鸡在四周龄前喂食生物素含量低的日粮，然后禁食18小时。三只火鸡出现了脂肪肝和肾综合征（FLKS）的临床症状，尸检时肝脏和肾脏苍白且肿大。形态学研究显示肝脏、肾脏、心脏和腺胃有脂肪堆积，但没有炎症或退行性变化的迹象。浸润的脂质具有异常的脂肪酸组成，单不饱和脂肪酸比例增加。患病火鸡患有严重低血糖症，肝糖原耗尽。这些发现表明，FLKS可在火鸡中通过实验诱导产生。
