Bain J M
Aust J Biol Sci. 1977 Apr;30(1-2):57-70.
The structure of the tissue from the liver, kidneys, pancreas and adrenal glands of 4-week-old chickens showing symptoms of the fatty liver and kidney syndrome (FLKS) was compared with that of normal tissue and related to the amount of biotin present in the liver tissue. These birds were reared with different levels of dietary biotin and were stressed by removal of food before being killed. Birds with less than 1-5 microgram biotin/g liver were considered to be deficient in biotin. In the stressed birds the severity of FLKS increased with decreasing levels of biotin. No lesions were found in the liver and kidney tissue of the birds with severe FLKS. Large quantities of fat were accumulated in the hepatocytes and intercellular spaces of the liver tissue, but the cell contents were not disorganized. In the kidney, conspicuous fat accumulation occurred in the proximal convoluted tubule cells and some ultrastructural disorganization of the cell contents was evident. No structural changes were found in the tissue of the pancreas or the adrenal glands of chickens suffering from severe FLKS.
将出现脂肪肝和肾综合征（FLKS）症状的4周龄雏鸡的肝脏、肾脏、胰腺和肾上腺组织的结构与正常组织的结构进行了比较，并与肝脏组织中生物素的含量相关联。这些鸡用不同水平的日粮生物素饲养，并在处死前通过禁食使其处于应激状态。肝脏中生物素含量低于1 - 5微克/克的鸡被认为生物素缺乏。在应激的鸡中，FLKS的严重程度随着生物素水平的降低而增加。患有严重FLKS的鸡的肝脏和肾脏组织中未发现病变。肝脏组织的肝细胞和细胞间隙中积累了大量脂肪，但细胞内容物没有紊乱。在肾脏中，近端曲管细胞中出现明显的脂肪积累，并且细胞内容物的一些超微结构紊乱很明显。患有严重FLKS的鸡的胰腺或肾上腺组织中未发现结构变化。
