Gibbs R S, Jones P M, Wilder C J
Obstet Gynecol. 1978 Jul;52(1):31-7.
A prospective clinical and microbiologic study was carried out on 413 indigent patients undergoing cesarean section. Operative site infection developed in 160 (38.5%). Initial treatment with penicillin and kanamycin was successful in 125 of these 160 infections (78%). Thirty-five patients (22%) failed to respond to penicillin and kanamycin and were treated with clindamycin or chloramphenicol. Twenty-eight of the 35 responded promptly to the additional antibiotic therapy. The remaining 7 patients (4%) had either abscesses, hematomas, or presumed septic pelvic thrombophlebitis. Among patients with anaerobic cultures, B fragilis was isolated with 12% with a good response to penicillin-kanamycin, but from 53% with a poor response to penicillin-kanamycin and with a good response to clindamycin or chloramphenicol. Similar critical evaluations of other antibiotic regimens are needed.
对413名接受剖宫产的贫困患者进行了一项前瞻性临床和微生物学研究。160名患者（38.5%）发生了手术部位感染。在这160例感染中，125例（78%）最初使用青霉素和卡那霉素治疗成功。35名患者（22%）对青霉素和卡那霉素无反应，改用克林霉素或氯霉素治疗。35名患者中有28名对额外的抗生素治疗迅速产生反应。其余7名患者（4%）发生了脓肿、血肿或疑似感染性盆腔血栓性静脉炎。在厌氧培养的患者中，脆弱拟杆菌的分离率为12%，对青霉素-卡那霉素反应良好，但在对青霉素-卡那霉素反应不佳且对克林霉素或氯霉素反应良好的患者中分离率为53%。需要对其他抗生素治疗方案进行类似的严格评估。
