Gilstrap L C, Maier R C, Gibbs R S, Connor K D, St Clair P J
Obstet Gynecol. 1984 Dec;64(6):762-6.
Piperacillin, a new semisynthetic penicillin, has broad spectrum activity against most clinically important aerobic and anaerobic bacteria. In the present study, piperacillin was compared with a combination of clindamycin and gentamicin for the treatment of 83 women with pelvic infection (42 with endometritis, 29 with posthysterectomy cuff infections, 11 with acute salpingitis, and one with a wound infection). There were 179 bacterial isolates, 98 (53%) aerobic and 81 (45%) anaerobic. Of the 42 patients treated with piperacillin, there were three (7.1%) clinical failures compared with one (2.4%) in the 41 patients treated with clindamycin-gentamicin. A single drug, piperacillin, was shown to be as safe and effective as the combined clindamycin plus gentamicin therapy for pelvic infections.
哌拉西林是一种新型半合成青霉素，对大多数临床上重要的需氧菌和厌氧菌具有广谱活性。在本研究中，将哌拉西林与克林霉素和庆大霉素联合用药进行比较，以治疗83例盆腔感染女性患者（42例子宫内膜炎、29例子宫切除术后袖口感染、11例急性输卵管炎和1例伤口感染）。共分离出179株细菌，98株（53%）为需氧菌，81株（45%）为厌氧菌。在接受哌拉西林治疗的42例患者中，有3例（7.1%）临床治疗失败，而在接受克林霉素-庆大霉素治疗的41例患者中有1例（2.4%）临床治疗失败。结果表明，对于盆腔感染，单一药物哌拉西林与克林霉素加庆大霉素联合治疗一样安全有效。
