头孢呋辛在正常妊娠及合并水肿或羊水过少的妊娠中的胎盘转运情况。
Transplacental transfer of cefuroxime in uncomplicated pregnancies and those complicated by hydrops or changes in amniotic fluid volume.
作者信息
Holt D E, Fisk N M, Spencer J A, de Louvois J, Hurley R, Harvey D
机构信息
Royal Postgraduate Medical School's Institute of Obstetrics and Gynaecology, Queen Charlotte's and Chelsea Hospital, London.
出版信息
Arch Dis Child. 1993 Jan;68(1 Spec No):54-7. doi: 10.1136/adc.68.1_spec_no.54.
The transplacental transfer of cefuroxime was determined at antenatal fetal blood sampling in a cross sectional study of 78 patients between 15-35 weeks' gestation, 8-138 minutes after a maternal intravenous dose of 750 mg. Mean serum cefuroxime concentration, measured by high performance liquid chromatography, was 7.4 (95% confidence interval (CI) 6.8 to 8.1) mg/l in control fetuses; concentrations in hydropic fetuses were similar (6.2 mg/l, CI 4.7 to 7.7) but in fetuses with oligohydramnios they were significantly lower, (4.9 mg/l, CI 3.6 to 6.2). Antibiotic concentration did not correlate with gestational age and remained unchanged by transfusion of packed red cells. We conclude that (i) fetal serum concentrations of cefuroxime obtained after a maternal dose of 750 mg are only adequate for prophylaxis against organisms with a minimum inhibitory concentration of < 4 mg/l and (ii) transplacental passage of cefuroxime is significantly reduced in the presence of oligohydramnios.
在一项横断面研究中，对78例妊娠15 - 35周的患者进行产前胎儿采血，测定头孢呋辛的经胎盘转运情况。在孕妇静脉注射750 mg后8 - 138分钟进行采血。通过高效液相色谱法测定，对照胎儿的平均血清头孢呋辛浓度为7.4（95%置信区间（CI）6.8至8.1）mg/l；水肿胎儿的浓度相似（6.2 mg/l，CI 4.7至7.7），但羊水过少胎儿的浓度显著降低（4.9 mg/l，CI 3.6至6.2）。抗生素浓度与胎龄无关，输注浓缩红细胞后浓度也无变化。我们得出结论：（i）孕妇剂量750 mg后获得的胎儿血清头孢呋辛浓度仅足以预防最低抑菌浓度<4 mg/l的微生物；（ii）羊水过少时，头孢呋辛的经胎盘转运显著减少。
Zotero 插件