Cannon J G, Kluger M J
Science. 1983 May 6;220(4597):617-9. doi: 10.1126/science.6836306.
Plasma obtained from human subjects after exercise and injected intraperitoneally into rats elevated rat rectal temperature and depressed plasma iron and zinc concentrations. The pyrogenic component was heat-denaturable and had an apparent molecular weight of 14,000 daltons. Human mononuclear leukocytes obtained after exercise and incubated in vitro released a factor into the medium that also elevated body temperature in rats and reduced trace metal concentrations. These results suggest that endogenous pyrogen, a protein mediator of fever and trace metal metabolism during infection, is released during exercise.
从人体受试者运动后获取的血浆，经腹腔注射到大鼠体内，可使大鼠直肠温度升高，并降低血浆中铁和锌的浓度。致热成分可被热变性，其表观分子量为14,000道尔顿。运动后获取的人单核白细胞在体外培养时，会向培养基中释放一种因子，该因子也会使大鼠体温升高，并降低痕量金属浓度。这些结果表明，内源性热原，一种感染期间发热和痕量金属代谢的蛋白质介质，在运动时会被释放出来。
