McLeod B C, Viernes A, Sassetti R J
Transfusion. 1983 Mar-Apr;23(2):143-7. doi: 10.1046/j.1537-2995.1983.23283172853.x.
Because of their structural similarity to dialysis membranes, six plasma separator membranes were evaluated for the ability to activate complement, as judged by immunoconversion of the third component of complement in crossed immunoelectrophoresis. A polysulfone and two cellulose acetate membranes were relatively strong alternative pathway activators. Polypropylene, poly[vinylidine fluoride] and polyvinyl-chloride derivative membranes were weak activators in some sera. Membrane activation was inhibited in citrate-anticoagulated but not in heparin-anticoagulated plasma. The results of such in vitro screening should be of value in selecting materials and anticoagulation regimens for membrane plasma separators.
由于六种血浆分离器膜在结构上与透析膜相似，因此通过交叉免疫电泳中补体第三成分的免疫转化来判断，对它们激活补体的能力进行了评估。一种聚砜膜和两种醋酸纤维素膜是相对较强的替代途径激活剂。聚丙烯、聚偏二氟乙烯和聚氯乙烯衍生物膜在某些血清中是较弱的激活剂。膜激活在枸橼酸盐抗凝血浆中受到抑制，但在肝素抗凝血浆中未受抑制。这种体外筛选结果对于选择膜血浆分离器的材料和抗凝方案应该是有价值的。
