Wenz B
Transfusion. 1983 Mar-Apr;23(2):95-8. doi: 10.1046/j.1537-2995.1983.23283172868.x.
Seventy-four patients with chronic transfusion requirements and histories of repetitive febrile reactions were transfused with 1138 units of microaggregate-filtered red cells. The filtered blood was prepared using either a direct interception or a depth filter. One-half of the units were centrifuged immediately prior to filtration. Microaggregate filtration reduced the overall incidence of febrile transfusion reactions by 77 percent. The centrifugation-filtration protocol reduced the rate of reactions by 98 percent. There were no differences between the ability of the different filters to reduce the reaction rate; however, red cell loss was twice as large with the depth filter as with the direct interception filter. The numerical criterion for "leukocyte-poor blood" was met in all units processed by centrifugation-filtration. Only units processed during the last 2 weeks of shelf-life fulfilled this criterion when centrifugation was omitted from the procedure. The majority of the latter units were clinically tolerated well due to their reduced granulocyte content.
74例有长期输血需求且有反复发热反应病史的患者输注了1138单位经微聚体过滤的红细胞。过滤血液采用直接截留法或深层过滤法制备。一半的单位在过滤前立即进行离心。微聚体过滤使发热性输血反应的总体发生率降低了77%。离心过滤方案使反应率降低了98%。不同过滤器降低反应率的能力没有差异；然而，深层过滤器造成的红细胞损失是直接截留过滤器的两倍。在所有经离心过滤处理的单位中都达到了“少白细胞血液”的数值标准。只有在保质期最后2周处理的单位，若在操作过程中省略离心步骤，才符合该标准。由于粒细胞含量降低，后一组中的大多数单位在临床上耐受性良好。
