Kupari M, Eriksson C J, Heikkilä J, Ylikahri R
Acta Med Scand. 1983;213(2):91-8.
To evaluate the hemodynamic changes related to alcohol flush, the effects of ethanol intake (0.5 g/kg) were studied by echocardiography and systolic time intervals in 10 Finnish and 9 Japanese healthy volunteers. In 5 Japanese subjects, post-drink facial flush was associated with elevated blood acetaldehyde (peak levels 20-83 mumol/l) and marked cardiocirculatory stimulation. Heart rate was increased directly post ingestion by 65% (p less than 0.01), stroke index by 23% (p less than 0.05), and cardiac index by 106% (p less than 0.05). Diastolic blood pressure was simultaneously decreased by 23% (p less than 0.05), peripheral vascular resistance by 54% (p less than 0.01), and circumferential wall stress by 22% (p less than 0.05); ejection fraction was raised by 26% (p less than 0.01). The other Japanese and the Finnish subjects had no detectable acetaldehyde in blood after ethanol ingestion. The average hemodynamic alterations in them were similar in direction to the changes presented above, but quantitatively 6-10 times smaller (p less than 0.005 for each of these variables). Thus, in Orientals with genetically defective acetaldehyde oxidation, ingestion of even small amounts of alcohol evokes intense enhancement of left ventricular function, probably because of acetaldehyde-induced catecholamine release and peripheral vasodilation.
为评估与酒精性脸红相关的血流动力学变化，通过超声心动图和收缩期时间间期，对10名芬兰健康志愿者和9名日本健康志愿者摄入乙醇（0.5 g/kg）的影响进行了研究。在5名日本受试者中，饮酒后脸红与血液中乙醛水平升高（峰值水平为20 - 83 μmol/l）及明显的心脏循环系统刺激有关。摄入乙醇后，心率直接增加65%（p < 0.01），每搏指数增加23%（p < 0.05），心脏指数增加106%（p < 0.05）。同时，舒张压降低23%（p < 0.05），外周血管阻力降低54%（p < 0.01），圆周壁应力降低22%（p < 0.05）；射血分数升高26%（p < 0.01）。其他日本受试者和芬兰受试者在摄入乙醇后血液中未检测到乙醛。他们的平均血流动力学改变在方向上与上述变化相似，但在数量上小6 - 10倍（这些变量中的每一个p < 0.005）。因此，对于乙醛氧化存在遗传缺陷的东方人，即使摄入少量酒精也会引起左心室功能的强烈增强，这可能是由于乙醛诱导的儿茶酚胺释放和外周血管舒张所致。
