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乙醛在不同种族群体对急性剂量乙醇反应性介导中的作用。

The role of acetaldehyde in mediating reactivity to an acute dose of ethanol among different racial groups.

作者信息

Zeiner A R, Paredes A, Christensen H D

出版信息

Alcohol Clin Exp Res. 1979 Jan;3(1):11-8. doi: 10.1111/j.1530-0277.1979.tb04759.x.

DOI:10.1111/j.1530-0277.1979.tb04759.x
PMID:371444
Abstract

Physiologic changes after ingestion of alcohol were monitored in Chinese and white volunteers, and absorption rate, acetaldehyde concentration, facial flushing, and heart rate increases were correlated.

摘要

对中国和白人志愿者摄入酒精后的生理变化进行了监测，并将吸收率、乙醛浓度、面部潮红和心率增加进行了关联分析。

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The role of acetaldehyde in mediating reactivity to an acute dose of ethanol among different racial groups.乙醛在不同种族群体对急性剂量乙醇反应性介导中的作用。
Alcohol Clin Exp Res. 1979 Jan;3(1):11-8. doi: 10.1111/j.1530-0277.1979.tb04759.x.
2
Relationship between facial flushing and blood acetaldehyde levels after alcohol intake.
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Alcohol and the heart. Intense hemodynamic changes associated with alcohol flush in orientals.酒精与心脏。东方人酒精性脸红相关的强烈血流动力学变化。
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ALDH2*2 but not ADH1B*2 is a causative variant gene allele for Asian alcohol flushing after a low-dose challenge: correlation of the pharmacokinetic and pharmacodynamic findings.在低剂量激发试验后，亚洲人酒精性脸红的致病变异基因等位基因为乙醛脱氢酶2*2而非乙醇脱氢酶1B*2：药代动力学和药效学研究结果的相关性
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4-Methylpyrazole decreases salivary acetaldehyde levels in aldh2-deficient subjects but not in subjects with normal aldh2.4-甲基吡唑可降低醛脱氢酶2缺乏者唾液中的乙醛水平，但对醛脱氢酶2正常者无效。
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Biochemical correlates of ethanol-induced flushing in Orientals.东方人乙醇诱发脸红的生化关联
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Aspirin attenuation of alcohol-induced flushing and intoxication in Oriental and Occidental subjects.阿司匹林对东方和西方受试者酒精所致脸红及醉酒反应的减轻作用。
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Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele.亚洲人因变异型ALDH2*2基因等位基因呈杂合状态而对酒精中毒有部分保护作用的药代动力学和药效学基础。
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Opiate antagonist nalmefene inhibits ethanol-induced flushing in Asians: a preliminary study.阿片类拮抗剂纳美芬可抑制亚洲人乙醇诱发的脸红：一项初步研究。
Alcohol Clin Exp Res. 1988 Oct;12(5):705-12. doi: 10.1111/j.1530-0277.1988.tb00269.x.

引用本文的文献

1
Aldehyde Dehydrogenase Deficiency as Cause of Facial Flushing Reaction to Alcohol in Japanese.醛脱氢酶缺乏是日本人饮酒后面部潮红反应的原因
Alcohol Health Res World. 1995;19(1):48-49.
2
Genetic polymorphisms in alcohol metabolizing enzymes as related to sensitivity to alcohol-induced health effects.酒精代谢酶的遗传多态性与酒精引起的健康影响的敏感性有关。
Environ Health Prev Med. 1997 Jan;1(4):193-200. doi: 10.1007/BF02931216.
3
Alcohol consumption among racial/ethnic minorities: theory and research.少数族裔群体中的酒精消费：理论与研究
Alcohol Health Res World. 1998;22(4):233-41.
4
Acute toxicity of gasoline and some additives.汽油及某些添加剂的急性毒性
Environ Health Perspect. 1993 Dec;101 Suppl 6(Suppl 6):115-31. doi: 10.1289/ehp.93101s6115.
5
Between- and within-race variation in acute cardiovascular responses to alcohol: evidence for genetic determination in normal males in three races.
Behav Genet. 1986 Nov;16(6):585-98. doi: 10.1007/BF01066285.
6
Pharmacogenetics and ecogenetics.药物遗传学与生态遗传学。
Experientia. 1986 Oct 15;42(10):1148-54. doi: 10.1007/BF01941289.
7
Genotype of alcohol dehydrogenase and aldehyde dehydrogenase loci in Japanese alcohol flushers and nonflushers.日本酒精性脸红反应者和非脸红反应者中乙醇脱氢酶和乙醛脱氢酶基因座的基因型
Hum Genet. 1989 Apr;82(1):14-6. doi: 10.1007/BF00288263.
8
[Genetically-induced variability of alcohol metabolism and its effect on drinking behavior and predisposition to alcoholism].[酒精代谢的基因诱导变异性及其对饮酒行为和酒精中毒易感性的影响]
Z Rechtsmed. 1990;103(3):169-90. doi: 10.1007/BF00207339.
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Racial differences in alcohol sensitivity: a new hypothesis.酒精敏感性的种族差异：一个新假说。
Hum Genet. 1979 Oct 2;51(3):331-4. doi: 10.1007/BF00283404.