Inoue K, Fukunaga M, Yamasawa K
Pharmacol Biochem Behav. 1980 Aug;13(2):295-7. doi: 10.1016/0091-3057(80)90087-8.
Young healthy Japanese men were given 0.48 g ethanol/kg body weight orally. Those responding with a marked increase in heart rate after alcohol also exhibited facial flushing and had higher acetaldehyde levels than those not responding, in spite of similar blood alcohol levels. The activity of aldehyde dehydrogenase in erythrocytes was found to correlate significantly (r=-0.73, p < 0.01) with the increase in heart rate after alcohol drinking. It is suggested that erythrocyte aldehyde dehydrogenase activity affects or reflects blood acetaldehyde levels and physiological response to alcohol, and may prove useful as a marker for alcohol sensitivity in Orientals.
给年轻健康的日本男性口服0.48克乙醇/千克体重。饮酒后心率显著增加的人除了面部潮红外，尽管血液酒精水平相似，但乙醛水平高于无此反应的人。发现红细胞中乙醛脱氢酶的活性与饮酒后心率增加显著相关（r=-0.73，p<0.01）。提示红细胞乙醛脱氢酶活性影响或反映血液乙醛水平及对酒精的生理反应，可能作为东方人酒精敏感性的一个标志物。
