Fujii S, Konishi I, Ban C, Okamura H
Am J Obstet Gynecol. 1983 Apr 1;145(7):850-6. doi: 10.1016/0002-9378(83)90691-9.
Multiple subperitoneal nodules were produced in the abdominal cavities of guinea pigs treated with various doses of estradiol benzoate for 3 months. Gland-like structures with intervening fibrous stroma were observed in 20% of these nodules. These gland-like structures resembled adenomatoid tumors, but were composed of cells that resembled mesothelium, ciliated cells, and cells with mucin in the cytoplasm. Some parts were composed of cells that had a squamous appearance. In guinea pigs, pretreatment with estradiol benzoate followed by treatment with a combination of estradiol benzoate and progesterone for 1 to 3 months produced nodules with gland-like structures similar to those produced by estrogen treatment alone. However, the gland-like structures were composed only of cells that resembled mesothelium and cells with cilia. Therefore, we conjecture that the formation of gland-like structures in the subperitoneal nodules is the result of mesothelial inclusions and their proliferation and that some of these mesothelial cells were differentiated into ciliated, mucinous, and squamous cells by estrogen.
用不同剂量的苯甲酸雌二醇处理豚鼠3个月，在其腹腔内产生了多个腹膜下结节。在这些结节中，20%观察到有腺样结构，其间有纤维性间质。这些腺样结构类似于腺瘤样肿瘤，但由类似于间皮细胞、纤毛细胞以及胞质内有黏液的细胞组成。有些部分由具有鳞状外观的细胞组成。在豚鼠中，先用苯甲酸雌二醇预处理，然后用苯甲酸雌二醇和孕酮联合处理1至3个月，产生的结节具有类似于仅用雌激素处理所产生的腺样结构。然而，这些腺样结构仅由类似于间皮的细胞和有纤毛的细胞组成。因此，我们推测腹膜下结节中腺样结构的形成是间皮包涵体及其增殖的结果，并且这些间皮细胞中的一些被雌激素分化为纤毛细胞、黏液细胞和鳞状细胞。
