Fujii S, Konishi I, Okamura H, Kawaguchi K, Ida K
Nihon Sanka Fujinka Gakkai Zasshi. 1984 Jan;36(1):1-7.
Glandlike structures with intervening fibrous stroma were observed in about 20% of subperitoneal nodules produced in the abdominal cavities of guinea pigs treated with various doses of estradiol benzoate (E) for 3 months. These glandlike structures were composed of cells resembling mesothelium, ciliated cells, cells with mucin in the cytoplasm and cells with a squamous appearance. Glandlike structures similar to those following estrogen treatment alone were also observed in about 20% of the nodules produced in the guinea pigs by pre-treatment with E and followed by combination treatment with E and progesterone (P) for 1 to 3 months. However, the glandlike structures were composed only of cells resembling mesothelium and cells with cilia. Both of these glandlike structures resembled adenomatoid tumors. We therefore conjecture that the formation of gland-like structures in the subperitoneal nodules is the result of mesothelial inclusions and their proliferation, and that some of these mesothelial cells were differentiated into ciliated, mucinous and squamous cells by estrogen.
在用不同剂量苯甲酸雌二醇（E）处理3个月的豚鼠腹腔内产生的腹膜下结节中，约20%观察到有腺样结构及其间的纤维性间质。这些腺样结构由类似间皮的细胞、纤毛细胞、胞质内有黏液的细胞和外观呈鳞状的细胞组成。在用E预处理豚鼠，然后E与孕酮（P）联合处理1至3个月所产生的结节中，约20%也观察到了与单独雌激素处理后相似的腺样结构。然而，这些腺样结构仅由类似间皮的细胞和有纤毛的细胞组成。这两种腺样结构均类似腺瘤样肿瘤。因此，我们推测腹膜下结节中腺样结构的形成是间皮包涵体及其增殖的结果，并且这些间皮细胞中的一些被雌激素分化为纤毛细胞、黏液细胞和鳞状细胞。
