Aronstein W S, Norden A P, Strand M
Am J Trop Med Hyg. 1983 Mar;32(2):334-42. doi: 10.4269/ajtmh.1983.32.334.
A monoclonal antibody has been used to identify and characterize an antigenic tegumental surface membrane glycoprotein of Schistosoma mansoni. Direct binding of 125I-labeled monoclonal antibody showed that this glycoprotein was present in eggs, cercariae, and worms of both sexes. The glycoprotein had an apparent molecular weight of 180,000. Indirect and direct immunofluorescent microscopy showed that this antigen was located on the interlinked tegumental folds of both larval and adult parasites. These findings are discussed in relation to parasite development and the mechanism by which schistosomes evade the host's immune defenses.
一种单克隆抗体已被用于鉴定和表征曼氏血吸虫抗原性皮层表面膜糖蛋白。125I标记的单克隆抗体的直接结合表明，这种糖蛋白存在于虫卵、尾蚴和雌雄成虫中。该糖蛋白的表观分子量为180,000。间接和直接免疫荧光显微镜检查表明，这种抗原位于幼虫和成虫寄生虫相互连接的皮层褶皱上。本文结合寄生虫发育以及血吸虫逃避宿主免疫防御的机制对这些发现进行了讨论。
