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延迟愈合实验模型中的电骨生长刺激

Electrical bone-growth stimulation in an experimental model of delayed union.

作者信息

Paterson D C, Carter R F, Maxwell G M, Hillier T M, Ludbrook J, Savage J P

出版信息

Lancet. 1977 Jun 18;1(8025):1278-81. doi: 10.1016/s0140-6736(77)91318-6.

Abstract

An experimental model has been devised for the consistent production of delayed bone healing of the tibia in adult dogs. A double-blind trial, with bias eliminated, was used to evaluate the use of a commercially available direct-current bone-growth stimulator with this model. The stimulator produced a statistically significant acceleration of bone healing at four weeks in the experimental model. Osteogenesis was normal, and no dysplastic, inflammatory, or neoplastic changes were found. This research has shown that electrical stimulation of bone is safe and augments bone formation. The bone-growth stimulator unit remains on trial, but in future it may alter the management of many difficult orthopaedic problems.

摘要

已设计出一种实验模型,用于在成年犬中持续诱导胫骨延迟性骨愈合。采用双盲试验以消除偏差,来评估一种市售的直流骨生长刺激器在此模型中的应用。在实验模型中,该刺激器在四周时使骨愈合在统计学上有显著加速。骨生成正常,未发现发育异常、炎症或肿瘤性改变。这项研究表明,对骨进行电刺激是安全的,并且可促进骨形成。该骨生长刺激器仍在试验中,但未来它可能会改变许多复杂骨科问题的治疗方式。

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