Norman J C, McGee M G, Fuqua J M, Igo S R, Turner S A, Sterling R, Urrutia C O, Frazier O H, Clay W C, Chambers J A
Artif Organs. 1983 Feb;7(1):64-73. doi: 10.1111/j.1525-1594.1983.tb04160.x.
A long-term, implantable, electrically actuated left ventricular assist system (THI/Gould LVAS) is being developed and characterized in vitro and in vivo for utilization in patients with end-stage heart disease. This system consists of five major components: a long-term, implantable blood pump (THI E-type ALVAD); an electrical-mechanical energy converter (Gould Model V); a control unit with batteries; a volume compensation system; and an external power supply and monitoring unit. Two of these components (blood pump and electrical-mechanical energy converter) have been integrated, and are undergoing chronic in vivo evaluations in calves. Thus far, 44 pneumatically and electrically actuated THI/Gould LVAS evaluations have been performed. This experience has resulted in greater than 6.5 years of actuation in vivo, with durations exceeding 1 year. System in vivo performance in terms of durability, mechanical reliability, hemodynamic effectiveness, and biocompatibility has been satisfactory. Demonstration of long-term (2-year) effectiveness in supporting the circulation is the ultimate goal.
一种长期植入式电动左心室辅助系统（THI/古尔德左心室辅助系统）正在体外和体内进行研发与特性研究，以供终末期心脏病患者使用。该系统由五个主要部件组成：一个长期植入式血泵（THI E型轴流心室辅助装置）；一个机电能量转换器（古尔德V型）；一个带电池的控制单元；一个容积补偿系统；以及一个外部电源和监测单元。其中两个部件（血泵和机电能量转换器）已集成在一起，并正在小牛身上进行长期体内评估。到目前为止，已经进行了44次气动和电动THI/古尔德左心室辅助系统评估。这些经验已使体内驱动时间超过6.5年，单次驱动持续时间超过1年。该系统在耐久性、机械可靠性、血液动力学有效性和生物相容性方面的体内性能令人满意。证明该系统在长期（2年）内支持循环的有效性是最终目标。
