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一种改进的体内（腹部）电动长期左心室辅助装置（“E型”全人工心脏）或部分人工心脏的理论设计考量与生理性能标准

THEORETICAL DESIGN CONSIDERATIONS AND PHYSIOLOGIC PERFORMANCE CRITERIA FOR AN IMPROVED INTRACORPOREAL (ABDOMINAL) ELECTRICALLY ACTUATED LONG-TERM LEFT VENTRICULAR ASSIST DEVICE ("E-TYPE" ALVAD) OR PARTIAL ARTIFICIAL HEART.

作者信息

Igo Stephen R., Hibbs C Wayne, Fuqua John M., Trono Ruben, Edmonds Charles H., Norman John C.

机构信息

Cardiovascular Surgical Research Laboratories, Texas Heart Institute of St. Luke's Episcopal and Texas Children's Hospitals, P.O. Box 20269, Houston, Texas 77025.

出版信息

Cardiovasc Dis. 1978 Jun;5(2):172-186.

PMID:15216070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC287725/
Abstract

Our laboratories are engaged in the design of a clinically-oriented electrically actuated long-term intracorporeal (abdominal) left ventricular assist device ("E-type" ALVAD) or partial artificial heart. This infradiaphragmatic blood pump is designed to be powered by implantable electrical to mechanical energy converter systems. THE FOLLOWING ANALYSES WERE UNDERTAKEN TO: [List: see text] The proposed "E-type" ALVAD should be capable of pumping 4-7 liters per minute at heart rates of 75-100 beats per minute during rest, and 10 liters per minute at rates of 120 beats per minute during moderate exercise. These performance levels should be exceeded with a maximum device stroke volume of 85-90 ml and a mean pump inflow (filling) impedance of </= 0.072 gm/sec/cm(-5).

摘要

我们的实验室正在致力于设计一种面向临床的电动长期体内（腹部）左心室辅助装置（“E型”ALVAD）或部分人工心脏。这种膈下血泵设计为由植入式电能到机械能转换系统提供动力。进行了以下分析：[列表：见正文]拟议的“E型”ALVAD应能够在静息时心率为75 - 100次/分钟的情况下每分钟泵血4 - 7升，在适度运动时心率为120次/分钟的情况下每分钟泵血10升。这些性能水平应在最大装置冲程容积为85 - 90毫升且平均泵流入（充盈）阻抗≤0.072克/秒/厘米⁻⁵的情况下被超越。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/f73dc80957be/cardiodis00014-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/d708ad4b5d18/cardiodis00014-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/650f63e540de/cardiodis00014-0091-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/b853884b616c/cardiodis00014-0092-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/a5e55d401eeb/cardiodis00014-0093-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/1b36801df6cb/cardiodis00014-0094-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/f73dc80957be/cardiodis00014-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/d708ad4b5d18/cardiodis00014-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/650f63e540de/cardiodis00014-0091-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/b853884b616c/cardiodis00014-0092-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/a5e55d401eeb/cardiodis00014-0093-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/1b36801df6cb/cardiodis00014-0094-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d849/287725/f73dc80957be/cardiodis00014-0095-a.jpg

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引用本文的文献

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Cardiovasc Dis. 1980 Sep;7(3):278-287.

本文引用的文献

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AN INTRACORPOREAL (ABDOMINAL) LEFT VENTRICULAR ASSIST DEVICE [ALVAD], XXX: CLINICAL READINESS AND INITIAL TRIALS IN MAN.一种体内（腹部）左心室辅助装置[ALVAD]，XXX：临床准备情况及人体首次试验
Cardiovasc Dis. 1976;3(3):249-288.
2
HEMODYNAMIC EFFECTS OF INTRACORPOREAL (ABDOMINAL) LEFT VENTRICULAR ASSIST DEVICE (ALVAD) PUMPING IN MAN, XL.体内（腹部）左心室辅助装置（ALVAD）在人体中泵血的血流动力学效应，XL。
Cardiovasc Dis. 1976;3(4):444-466.
3
IMPLICATIONS OF STUDIES OF VASCULAR IMPEDANCE FOR ASSESSMENT OF LEFT VENTRICULAR FUNCTION.血管阻抗研究对左心室功能评估的意义
Cardiovasc Dis. 1974;1(2):127-136.
4
Alteration of mechanical performance of the ventricle by intraaortic balloon counterpulsation.
Am J Cardiol. 1970 May;25(5):546-51. doi: 10.1016/0002-9149(70)90593-x.
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Hemodynamic and metabolic responses to vasodilator therapy in acute myocardial infarction.急性心肌梗死中血管扩张剂治疗的血流动力学和代谢反应。
Circulation. 1973 Dec;48(6):1183-93. doi: 10.1161/01.cir.48.6.1183.
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Nuclear-fueled circulatory support systems XII: current status.
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