Abelson M B, Udell I J, Weston J H
Arch Ophthalmol. 1983 Apr;101(4):631-3. doi: 10.1001/archopht.1983.01040010631021.
Compound 48/80 (N-methyl-p-methoxyphenethylamine formaldehyde condensation product) was used to selectively degranulate mast cells to induce conjunctival eosinophilia in 12 rabbits. Biopsy specimens of bulbar conjunctiva showed that eosinophils were present in all treated eyes. With repeated treatments the number of eosinophils increased; these cells were concentrated in the subepithelial and epithelial zones by day 3. Eosinophils were not found on scrapings of the bulbar conjunctiva in 75% of the rabbits that received single or multiple treatments. We conclude that deep and superficial eosinophil infiltration may be present even when eosinophils are not seen on conjunctival scrapings. Therefore, the absence of eosinophils in scrapings should not rule out the diagnosis of ocular allergy.
化合物48/80（N-甲基-对甲氧基苯乙胺甲醛缩合物）用于选择性地使肥大细胞脱颗粒，以诱导12只兔子发生结膜嗜酸性粒细胞增多。球结膜活检标本显示，所有治疗眼均有嗜酸性粒细胞存在。随着重复治疗，嗜酸性粒细胞数量增加；到第3天，这些细胞集中在上皮下和上皮区域。在接受单次或多次治疗的兔子中，75%的球结膜刮片中未发现嗜酸性粒细胞。我们得出结论，即使在结膜刮片中未见嗜酸性粒细胞，也可能存在深部和浅表嗜酸性粒细胞浸润。因此，刮片中嗜酸性粒细胞的缺失不应排除眼部过敏的诊断。
