Maitre M, Rumigny J F, Cash C, Mandel P
Biochem Biophys Res Commun. 1983 Jan 14;110(1):262-5. doi: 10.1016/0006-291x(83)91289-5.
gamma-Hydroxybutyrate binding sites, first described on crude membranes from rat brain, have been further studied on subcellular fractions. The nerve ending fraction (fraction C) exhibits the maximal capacity for GHB binding. The two classes of binding sites (high and low affinities) described for the crude membrane preparation are enriched in this synaptosomal fraction. This result is further evidence in favor of a role for GHB as a neurotransmitter or neuromodulator in rat brain.
γ-羟基丁酸结合位点最初是在大鼠脑粗膜上发现的，现已在亚细胞组分上进行了进一步研究。神经末梢组分（C组分）显示出γ-羟基丁酸结合的最大能力。粗膜制备中所描述的两类结合位点（高亲和力和低亲和力）在这个突触体组分中得到了富集。这一结果进一步证明了γ-羟基丁酸在大鼠脑中作为神经递质或神经调节剂发挥作用。
