Lindgren L, Saarnivaara L
Br J Anaesth. 1983 Apr;55(4):269-73. doi: 10.1093/bja/55.4.269.
Induction of anaesthesia with enflurane 5 vol% plus 70% nitrous oxide in oxygen was followed by suxamethonium 1, 1.5 or 2 mg kg-1 i.v. and the cardiovascular changes studied in 58 children. The eyelash reflex disappeared in 44 +/- 1.2 (SEM)s and the venepuncture could be performed 1.8 +/- 0.05 (SEM) min after the start of enflurane anaesthesia. The increase in systolic arterial pressure after tracheal intubation was less marked after enflurane than after thiopentone (taken from an earlier study). Heart rate increased significantly after all doses of suxamethonium, but no cardiac arrhythmias were seen. The QT interval was significantly prolonged by enflurane (P less than 0.001), but remained unchanged after suxamethonium.
采用5%体积分数的恩氟烷加70%氧化亚氮混合气体在氧气中诱导麻醉，随后静脉注射1、1.5或2mg/kg的琥珀酰胆碱，对58名儿童的心血管变化进行了研究。睫毛反射在44±1.2（标准误）秒时消失，在恩氟烷麻醉开始后1.8±0.05（标准误）分钟可进行静脉穿刺。气管插管后收缩压的升高在恩氟烷麻醉后不如硫喷妥钠麻醉后明显（取自早期研究）。所有剂量的琥珀酰胆碱注射后心率均显著增加，但未见心律失常。恩氟烷使QT间期显著延长（P<0.001），但琥珀酰胆碱注射后QT间期保持不变。
